As a new age of weight-loss therapeutics dawns, heralded by the likes of
semaglutide (Ozempic, Wegovy), scientists are one step closer to creating a
drug that can coax muscles into behaving as if they’ve just been put through
a vigorous workout. Known as exercise mimetics, this proposed class of
drugs essentially ‘mimics’ the benefits of exercise, triggering a mechanism
that supercharges fat metabolism and encourages lean muscle mass.
“This compound is basically telling skeletal muscle to make the same
changes you see during endurance training,” said lead author Thomas
Burris, professor of pharmacy at the University of Florida.
While exercise mimetics have been in the works for some time, the UF
researchers found that a compound known as SLU-PP-332 was able to
target a specific estrogen-related receptor (ERR), which boosted skeletal fat
oxidation, therefore increasing energy expenditure.
In a mouse study, SLU-PP-332 ‘revved’ up a natural metabolic pathway that
is normally excited through physical exercise. Compared to a control group
of obese mice, the cohort given SLU-PP-332 twice a day for a month gained
10 times less fat and also lost 12% of their body weight in the process, with
no changes to diet and exercise.
“They use more energy just living,” Burris said.
The mice were also able to run nearly 50% further than prior to treatment,
which supports previous research into how it strengthens the heart muscle.
“When you treat mice with the drug, you can see that their whole body

metabolism turns to using fatty acids, which is very similar to what people
use when they are fasting or exercising,” Burris added. “And the animals
start losing weight.”
The class of drugs is very different to the emerging weight-loss medicines
such as semaglutide, which drastically slow down digestion. However, this
could potentially be complementary, since rapid weight loss can also result
in a loss of lean muscle.
While still early days, researchers believe exercise mimetics can go far
beyond treating weight loss, to target all the conditions that physical activity
helps lower the risk of, including diabetes and cardiovascular disease. For
those who are limited in what exercise they can do, this could be life-
changing. Researchers are also studying how these compounds can benefit
brain function and cognitive health.
“This may be able to keep people healthier as they age,” Burris added.
The study was published in the Journal of Pharmacology and Experimental
Therapeutics.
Source: University of Florida via Medical Xpress